Vanguard Station was a Watchtower class space station in orbit of Ilum during the Clone Wars. During the height of the Clone Wars, it was under the command of Commodore Enwright, whose first officer was Commander Willard Decker.
In 21 BBY, the frigate Intrepid worked in conjunction with Vanguard Station in conducting a mission to investigate the loss of contact with solar system Gamma 7A in Sector 39J. Shortly after,Vanguard lost contact with the Intrepid and a rescue priority was issued to the Enterprise, which was already en route to the starbase. Following their investigation, the Enterprise returned to the base for a scheduled layover and shore leave.
Later that year, the Enterprise traveled to this base, where it rendezvoused with the Lexington, and was ordered to be refitted with the M-5 computer. All but twenty of the Enterprise's crew was offloaded to this base, where they were kept in a security holding area, while the ship proceeded to participate in a Starfleet battle simulation.